Happiness Under the Microscope: Part I

1413992_smile_more_worry_lessOur body recognizes that at a molecular level, happiness is not created equal. It responds in different ways that help or harm our health, according to a new study led by Barbara L. Fredrickson, Kenan Distinguished Professor of psychology in the College of Arts and Sciences at the University of North Carolina at Chapel Hill.

“A functional genomic perspective on human well-being” was published July 29 in Proceedings of the National Academy of Sciences.  Researchers found that a sense of well-being derived from “a noble purpose” may actually provide cellular health benefits. “Simple self-gratification” on the other hand, could possibly have negative effects, despite an “overall perceived sense of happiness.”

“Philosophers have long distinguished two basic forms of well-being: a ‘hedonic’ [hee-DON-ic] form representing an individual’s pleasurable experiences, and a deeper ‘eudaimonic,’ [u-DY-moh-nick] form that results from striving toward meaning and a noble purpose beyond simple self-gratification,” wrote Fredrickson and her colleagues.

“It’s the difference, for example, between enjoying a good meal and feeling connected to a larger community through a service project,” she said. “Both give us a sense of happiness, but each is experienced very differently in the body’s cells. “We know from many studies that both forms of well-being are associated with improved physical and mental health, beyond the effects of reduced stress and depression, but we have had less information on the biological bases for these relationships.”

Fredrickson and her colleagues are collaborating with a team from the University of California led by Steven W. Cole, the professor of medicine, psychiatry, and behavioral sciences. They’ve looked at the biological influence of hedonic and eudaimonic well-being through the human genome,  interested in the pattern of gene expression within people’s immune cells.

“Past work by Cole and colleagues had discovered a systematic shift in gene expression associated with chronic stress, a shift characterized by increased expression of genes involved in inflammation” that are implicated in a wide variety of human ills, including arthritis and heart disease, and “decreased expression of genes involved in … antiviral responses,” the study noted. Cole and colleagues coined the phrase “conserved transcriptional response to adversity” or CTRA to describe this shift. In short, the functional genomic fingerprint of chronic stress sets us up for illness, Fredrickson said.

However, if the fact that happiness is created equal, and equally opposite to ill-being is true, then patterns of gene expression should be the same regardless of hedonic or eudaimonic well-being. This is not so, the researchers found.

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“Eudaimonic well-being was, indeed, associated with a significant decrease in the stress-related CTRA gene expression profile. In contrast, hedonic well-being was associated with a significant increase in the CTRA profile. Their genomics-based analyses, the authors reported, reveal the hidden costs of purely hedonic well-being. Fredrickson found the results initially surprising, because study participants themselves reported overall feelings of well-being. One possibility, she suggested, is that people who experience more hedonic than eudaimonic well-being consume the emotional equivalent of empty calories.” “Their daily activities provide short-term happiness yet result in negative physical consequences long-term,” she said.

“We can make ourselves happy through simple pleasures, but those ‘empty calories’ don’t help us broaden our awareness or build our capacity in ways that benefit us physically,” she said. “At the cellular level, our bodies appear to respond better to a different kind of well-being, one based on a sense of connectedness and purpose.”

These results agree with Fredrickson’s previous studies on the effects of both positive emotions and a study linking a sense of connectedness with longevity. “Understanding the cascade to gene expression will help inform further work in these areas,” she added.

Sources: sciencedaily.com

Elizabeth Shaw

Elizabeth enjoys teaching and dancing as well as being a violinist in a local orchestra. She loves reading and writing materials that range everywhere from short stories and poetry to medical dictionaries and encyclopedias. She enjoys sharing her talent for the written word by being a regular contributor and test and training editor here at ProTrainings.

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